BDBM510922 1-methyl-6-{[(aR)- 6-[6-(2-hydroxy-2- methylpropoxy)pyrazolo [1,5-a]pyridine-3- amido]spiro[3.3] heptan-2-yl]oxy}-1H- pyrazolo[3,4- b]pyridine-5- carboxamide::US11078197, Example 101::US11673886, Example 101

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cnn5cc(OCC(C)(C)O)ccc45)C3)nc12

InChI Key InChIKey=HJIKLCYJAATTRS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510922   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510922(1-methyl-6-{[(aR)- 6-[6-(2-hydroxy-2- methylpropox...)
Affinity DataIC50: 6nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510922(1-methyl-6-{[(aR)- 6-[6-(2-hydroxy-2- methylpropox...)
Affinity DataIC50: 6.00E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent