BDBM510970 N-[(4s)-6-({5-carbamoyl- 1-methyl-1H-pyrazolo[3,4- b]pyridin-6- yl}oxy)spiro[3.3]heptan-2- yl]-5-[4- (trifluoromethyl)phenyl]- 1,3,4-thiadiazole-2- carboxamide::US11078197, Example 149::US11673886, Example 149

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4nnc(s4)-c4ccc(cc4)C(F)(F)F)C3)nc12

InChI Key InChIKey=CLSCWYTXNGHVMH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510970   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510970(N-[(4s)-6-({5-carbamoyl- 1-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50: 14.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510970(N-[(4s)-6-({5-carbamoyl- 1-methyl-1H-pyrazolo[3,4-...)
Affinity DataIC50: 1.45E+4nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent