BDBM510973 1-(4-cyanophenyl)-5- methyl-N-[(4s)-6-({5- carbamoyl-1-methyl-1H- pyrazolo[3,4-b]pyridin-6- yl}oxy)spiro[3.3]heptan-2- yl]-1H-pyrazole-4- carboxamide::US11078197, Example 152::US11673886, Example 152

SMILES Cc1c(cnn1-c1ccc(cc1)C#N)C(=O)N[C@H]1C[C@]2(C1)C[C@@H](C2)Oc1nc2n(C)ncc2cc1C(N)=O

InChI Key InChIKey=CMVOXXKJDRETSI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510973   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510973(1-(4-cyanophenyl)-5- methyl-N-[(4s)-6-({5- carbamo...)
Affinity DataIC50: 6.30nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510973(1-(4-cyanophenyl)-5- methyl-N-[(4s)-6-({5- carbamo...)
Affinity DataIC50: 6.30E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent