BDBM510974 5-methyl-1-[4-(1-methyl- 1H-pyrazol-4-yl)phenyl]- N-[(4s)-6-({5-carbamoyl- 1-methyl-1H-pyrazolo[3,4- b]pyridin-6- yl}oxy)spiro[3.3]heptan-2- yl]-1H-pyrazole-4- carboxamide::US11078197, Example 153::US11673886, Example 153

SMILES Cc1c(cnn1-c1ccc(cc1)-c1cnn(C)c1)C(=O)N[C@H]1C[C@]2(C1)C[C@@H](C2)Oc1nc2n(C)ncc2cc1C(N)=O

InChI Key InChIKey=JONTYCWAFCMPQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510974   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510974(5-methyl-1-[4-(1-methyl- 1H-pyrazol-4-yl)phenyl]- ...)
Affinity DataIC50: 0.800nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510974(5-methyl-1-[4-(1-methyl- 1H-pyrazol-4-yl)phenyl]- ...)
Affinity DataIC50: 800nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent