BDBM510975 1-(difluoromethyl)-5-(4- methanesulfonylphenyl)- N-[(4s)-6-({5-carbamoyl- 1-methyl-1H-pyrazolo[3,4- b]pyridin-6- yl}oxy)spiro[3.3]heptan-2- yl]-1H-pyrazole-3- carboxamide::US11078197, Example 154::US11673886, Example 154

SMILES Cn1ncc2cc(C(N)=O)c(O[C@H]3C[C@@]4(C[C@@H](C4)NC(=O)c4cc(-c5ccc(cc5)S(C)(=O)=O)n(n4)C(F)F)C3)nc12

InChI Key InChIKey=DBMVIWKTNLRLHS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 510975   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510975(1-(difluoromethyl)-5-(4- methanesulfonylphenyl)- N...)
Affinity DataIC50: 2.30nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM510975(1-(difluoromethyl)-5-(4- methanesulfonylphenyl)- N...)
Affinity DataIC50: 2.30E+3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent