BDBM511543 US11059794, Example 6.05::tert-butyl 4-[(5-sulfamoyl-1,3- thiazol-2-yl)sulfonyl]piperidine-1- carboxylate (intermediate 15.2)/3- [2-[(5-methyltetrazol-2-yl)methyl]- 4- (trifluoromethyl)phenyl]propanoic acid (CAS-RN 1646783-83-6)

SMILES Cc1nnn(Cc2cc(ccc2CCC(=O)N2CCC(CC2)S(=O)(=O)c2ncc(s2)S(N)(=O)=O)C(F)(F)F)n1

InChI Key InChIKey=VFRMHKODPXUZLQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511543   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511543(tert-butyl 4-[(5-sulfamoyl-1,3- thiazol-2-yl)sulfo...)
Affinity DataIC50: 6nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCarbonic anhydrase 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511543(tert-butyl 4-[(5-sulfamoyl-1,3- thiazol-2-yl)sulfo...)
Affinity DataIC50: 10nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent