BDBM511567 US11059794, Example 6.27::tert-butyl 4-(2,3-difluoro-4- sulfamoylphenyl)sulfonylpiperidine- 1-carboxylate (intermediate 15)/2- cyclopropyl-6-(oxan-4- ylmethoxy)pyridine-4-carboxylic acid (CAS-RN 1810776-23-8)

SMILES NS(=O)(=O)c1ccc(c(F)c1F)S(=O)(=O)C1CCN(CC1)C(=O)c1cc(OCC2CCOCC2)nc(c1)C1CC1

InChI Key InChIKey=IHDSOHZJFSYDSW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 511567   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511567(tert-butyl 4-(2,3-difluoro-4- sulfamoylphenyl)sulf...)
Affinity DataIC50: 1nMAssay Description:ATX inhibition was measured by a fluorescence quenching assay using a specifically labeled substrate analogue (MR121 substrate). To obtain this MR121...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetCarbonic anhydrase 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM511567(tert-butyl 4-(2,3-difluoro-4- sulfamoylphenyl)sulf...)
Affinity DataIC50: 9.20nMAssay Description:Human carbonic anhydrase II (hCA-II) inhibition was measured by an absorbance method using 4-nitrophenyl acetate (4-NPA) as its substrate. 4-NPA can ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent