BDBM511638 US11059801, Compound D-1::US11059801, Compound D-57

SMILES Oc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

InChI Key InChIKey=XMPJICVFSDYOEG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 511638   

TargetDNA damage-binding protein 1/Protein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM511638(US11059801, Compound D-1 | US11059801, Compound D-...)
Affinity DataIC50: 28.9nMAssay Description:A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetDNA damage-binding protein 1/Protein cereblon(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM511638(US11059801, Compound D-1 | US11059801, Compound D-...)
Affinity DataIC50: 87nMAssay Description:A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetProtein cereblon(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM511638(US11059801, Compound D-1 | US11059801, Compound D-...)
Affinity DataIC50: 630nMAssay Description:Displacement of fluorescent tracer from NanoLuc-tagged CRBN (unknown origin) by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed