BDBM512435 1-(2-chlorophenyl)-4-(((1R,2S)-2- fluorocyclopropyl)amino)-7- (trifluoromethyl)pyrido[2,3- d]pyrimidin-2(1H)-one, single unknown enantiomer::US11084798, Cpd No 771::US11130759, Cpd. No. 771

SMILES F[C@H]1C[C@@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F

InChI Key InChIKey=GYESABLLTMWWPD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 512435   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM512435(US11130759, Cpd. No. 771 | US11084798, Cpd No 771 ...)
Affinity DataIC50: 200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM512435(US11130759, Cpd. No. 771 | US11084798, Cpd No 771 ...)
Affinity DataIC50: 200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2022
Entry Details
US Patent