BDBM514379 US11059828, Example 387

SMILES Fc1cc2cnc(nc2cc1F)N1CC2CN(CC2C1)C(=O)c1cccc(F)c1-c1ncccn1

InChI Key InChIKey=WTVORTBENOIIJS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 514379   

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM514379(US11059828, Example 387)
Affinity DataKi:  16nMAssay Description:HEK293 stably expressing human orexin-2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco, Cat #11039), in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM514379(US11059828, Example 387)
Affinity DataKi:  437nMAssay Description:Chinese ovary cells (CHO) stably expressing human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12 (Gibco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/2/2022
Entry Details
US Patent