BDBM514632 US11098029, Example 67

SMILES COC(=O)N1[C@H](C)C[C@H](NS(=O)(=O)N(C)C)[C@@H]1CO[C@H]1CC[C@H](CC1)c1cccc(F)c1

InChI Key InChIKey=VRCBPPQSWQSLSW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 514632   

TargetOrexin receptor type 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM514632(US11098029, Example 67)
Affinity DataIC50: 0.230nMAssay Description:Agonist activity at human recombinant OX2R expressed in CHOK1 cells assessed as increase in intracellular Ca2+ mobilization by measuring IP3 producti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetOrexin receptor type 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM514632(US11098029, Example 67)
Affinity DataIC50: 0.460nMAssay Description:In a typical experiment, the OX1 and OX2 receptor agonist activity is determined in accordance with the following general experimental method. Chines...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2022
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM514632(US11098029, Example 67)
Affinity DataIC50: 0.460nMAssay Description:Agonist activity at human recombinant OX2R expressed in CHOK1 cells assessed as increase in intracellular Ca2+ mobilization by measuring IP3 producti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed