BDBM515330 US11110088, Compound Table 1.4

SMILES COc1cc(ccc1C(=O)Nc1nccs1)-c1nc([C@@H]2CCCN2C(=O)C#CC)n2ccnc(N)c12

InChI Key InChIKey=CDFHNEWIEMNZKE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 515330   

TargetTyrosine-protein kinase BTK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515330(US11110088, Compound Table 1.4)
Affinity DataIC50: 3.90nMAssay Description:BTK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.BTK enzyme (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetTyrosine-protein kinase TXK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515330(US11110088, Compound Table 1.4)
Affinity DataIC50: 7.10nMAssay Description:TXK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.TXK enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetTyrosine-protein kinase Tec(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515330(US11110088, Compound Table 1.4)
Affinity DataIC50: 7.20nMAssay Description:TEC enzyme (Millipore #14-801M), is diluted to 2 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, pH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515330(US11110088, Compound Table 1.4)
Affinity DataIC50: 12nMAssay Description:BMX enzyme (Millipore #14-499M), is diluted to 0.5 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.1% NaN3, 1 mM DTT, 2 mM MnCl2, p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515330(US11110088, Compound Table 1.4)
Affinity DataIC50: 1.00E+3nMAssay Description:EGFR enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.EGFR enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Acerta Pharma

US Patent
LigandPNGBDBM515330(US11110088, Compound Table 1.4)
Affinity DataIC50: 1.00E+3nMAssay Description:ITK enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.ITK enzyme (M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent