BDBM516065 US11053238, Compound 16a

SMILES CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5COC[C@@H](C)n5c4c3)nc2)CC1

InChI Key InChIKey=PDJVJMYVUAQPLU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 516065   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516065(US11053238, Compound 16a)
Affinity DataIC50: 17.6nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 4/6(Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516065(US11053238, Compound 16a)
Affinity DataIC50: 300nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent