BDBM516678 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-methyl-2H-tetrazol-5-yl)-1,3,4,7-tetrahydro-2H-pyrazolo[4′,3′:5,6]pyrido[4,3-d]pyrimidin-2-one::US11053246, Example 95

SMILES CN\N=C(/N=N)N1C(=O)N(Cc2cnc3[nH]ncc3c12)c1c(F)c(OC)cc(OC)c1F

InChI Key InChIKey=LIBZGICDTVKQSD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 516678   

TargetFibroblast growth factor receptor 1(Human)
Incyte

US Patent
LigandPNGBDBM516678(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-methyl-2...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Incyte

US Patent
LigandPNGBDBM516678(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-methyl-2...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Incyte

US Patent
LigandPNGBDBM516678(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-(2-methyl-2...)
Affinity DataIC50: 100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent