BDBM517149 5-[(6-methoxy-3-pyridyl)methyl]-6- methyl-1-tetrahydropyran-4-yl- pyrazolo[4,3-c]pyridin-4-one::US11104680, Example 18::US11104680, Example 19::US11104680, Example 25

SMILES COc1ccc(Cn2c(C)cc3n(ncc3c2=O)C2CCOCC2)cc1

InChI Key InChIKey=LWAQPJWARNOJEY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 517149   

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 88nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 113nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 171nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 184nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 370nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 644nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 738nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 825nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent

LigandPNGBDBM517149(US11104680, Example 25 | 5-[(6-methoxy-3-pyridyl)m...)
Affinity DataIC50: 1.17E+3nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
US Patent