BDBM518079 8-(cyclopropanecarbonyl)-4-[(2R)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxy-propyl]- 2,3-dihydro-1,4-benzoxazepin-5-one::US11111237, Example 216::US11725001, Example 216

SMILES O[C@H](CN1CCc2ccccc2C1)CN1CCOc2cc(ccc2C1=O)C(=O)C1CC1

InChI Key InChIKey=CYWLSSFVRSJDOY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518079   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM518079(US11111237, Example 216 | 8-(cyclopropanecarbonyl)...)
Affinity DataIC50: 50nMAssay Description:The histone H4 peptide was diluted with carbonate-bicarbonate buffer and prepared to 100 μg/mL, and then dispensed onto the plate per 100 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2023
Entry Details
US Patent

TargetProtein arginine N-methyltransferase 5(Human)
Sk Biopharmaceuticals

US Patent
LigandPNGBDBM518079(US11111237, Example 216 | 8-(cyclopropanecarbonyl)...)
Affinity DataIC50: 50nMAssay Description:Experimental procedure: The histone H4 peptide was diluted with carbonate-bicarbonate buffer and prepared to 100 μg/mL, and then dispensed onto ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent