BDBM518263 5-Fluoro-7-methoxy-2-(5-pyrimidin-2-ylpyrazin-2-yl)-3,4-dihydro-1H-isoquinoline::US11124495, Example 8

SMILES COc1cc(F)c2CCN(Cc2c1)c1cnc(cn1)-c1ncccn1

InChI Key InChIKey=REXMSGDXGJZHBX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 518263   

TargetLarge envelope protein(HBV-D)
Hoffmann-La Roche

US Patent
LigandPNGBDBM518263(5-Fluoro-7-methoxy-2-(5-pyrimidin-2-ylpyrazin-2-yl...)
Affinity DataIC50: 292nMAssay Description:The assay employs real-time qPCR (TaqMan) to directly measure extracellular HBV DNA copy number in the cell supernatant. HepG2.2.15 cells were plated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetLarge envelope protein(HBV-D)
Hoffmann-La Roche

US Patent
LigandPNGBDBM518263(5-Fluoro-7-methoxy-2-(5-pyrimidin-2-ylpyrazin-2-yl...)
Affinity DataIC50: 445nMAssay Description:HepG2.2.15 cells were seeded in duplicate into white, 96-well plates at 1.5×104 cells/well. The cells were treated with a three-fold serial dilution ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent