BDBM518402 1-[2-(2-Cyclopropylpyrimidin-5-yl)ethyl]-3-[6-(4-isopropyl-1,2,4-triazol-3-yl)-2-pyridyl]imidazolidin-2-one::US11124496, Example 4

SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCN(CCc2cnc(nc2)C2CC2)C1=O

InChI Key InChIKey=XBSNABBUEGDTLH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 518402   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Eli Lilly

US Patent
LigandPNGBDBM518402(US11124496, Example 4 | 1-[2-(2-Cyclopropylpyrimid...)
Affinity DataIC50: 13.7nMAssay Description:The purpose of this assay is to determine the effect of ASK1 inhibitors on the production of ADP by ASK1. The recombinant human ASK1 (hASK1) catalyti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent