BDBM518537 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one::US11124518, Example 12::US11299493, Compound 1.5

SMILES CN1Cc2cc(Nc3ncc4c(n3)n(-c3cccc(n3)C(C)(C)O)n(CC=C)c4=O)ccc2C(C)(C)C1

InChI Key InChIKey=DDEWQOWVNDYQSR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 518537   

TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM518537(US11124518, Example 12 | 2-Allyl-1-(6-(2-hydroxypr...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human full length GST-tagged WEE1 expressed in insect cells incubated for 15 mins followed by ATP addition by ADP Glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM518537(US11124518, Example 12 | 2-Allyl-1-(6-(2-hydroxypr...)
Affinity DataIC50: 3.10nMAssay Description:IC50 values of compounds against WEE1 kinase enzyme were determined by LanthaScreen Terbium Labeled TR-FRET assay. Kinase assays were performed in 1×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent

TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM518537(US11124518, Example 12 | 2-Allyl-1-(6-(2-hydroxypr...)
Affinity DataIC50: 10nMAssay Description:Wee 1 kinase was determined by using Flurorescence Resonance Energy Transfer (FRET) assay. In 384-well plates, Wee1 kinase (2 nM final concentration)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent

TargetWee1-like protein kinase(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM518537(US11124518, Example 12 | 2-Allyl-1-(6-(2-hydroxypr...)
Affinity DataIC50: 25nMAssay Description:Inhibition of WEE1 in human U2OS cells incubated for 1 hr by mesoscale discovery assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Emd Serono

Curated by ChEMBL
LigandPNGBDBM518537(US11124518, Example 12 | 2-Allyl-1-(6-(2-hydroxypr...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human N-terminal His6-tagged recombinant full-length PLK1 expressed in baculovirus infected Sf9 cells incubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed