BDBM519814 1,1,1,3,3,3- Hexafluoropropan- 2-yl 1-((5-(4- fluorophenyl)isoxazol-3- yl)methyl)-1,8- diazaspiro[4.5]decane- 8-carboxylate::US11142526, Example 39

SMILES Fc1ccc(cc1)-c1cc(CN2CCCC22CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)no1

InChI Key InChIKey=OTICTRAFUAMCIF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 519814   

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM519814(1,1,1,3,3,3- Hexafluoropropan- 2-yl 1-((5-(4- fluo...)
Affinity DataIC50: 100nMAssay Description:Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetMonoglyceride lipase(Mouse)
H. Lundbeck

US Patent
LigandPNGBDBM519814(1,1,1,3,3,3- Hexafluoropropan- 2-yl 1-((5-(4- fluo...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were administered to wild-type C57B1/6J by oral gavage in a vehicle of polyethylene glycol. Each animal was sacrificed 4 h following admin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent