BDBM519835 1,1,1,3,3,3- Hexafluoropropan- 2-yl 1-(6- chlorobenzo[b] thiophene-2- carbonyl)-1,8- diazaspiro[4.5] decane-8- carboxylate::US11142526, Example 60

SMILES FC(F)(F)C(OC(=O)N1CCC2(CCCN2C(=O)c2cc3ccc(Cl)cc3s2)CC1)C(F)(F)F

InChI Key InChIKey=PMPYKKYHMKHWLJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 519835   

TargetMonoglyceride lipase(Human)
H. Lundbeck

US Patent
LigandPNGBDBM519835(1,1,1,3,3,3- Hexafluoropropan- 2-yl 1-(6- chlorobe...)
Affinity DataIC50: 100nMAssay Description:Proteomes (human prefrontal cortex or cell membrane fractions) (50 μL, 1.0 mg/mL total protein concentration) were preincubated with varying con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

TargetMonoglyceride lipase(Mouse)
H. Lundbeck

US Patent
LigandPNGBDBM519835(1,1,1,3,3,3- Hexafluoropropan- 2-yl 1-(6- chlorobe...)
Affinity DataIC50: 100nMAssay Description:Inhibitors were administered to wild-type C57B1/6J by oral gavage in a vehicle of polyethylene glycol. Each animal was sacrificed 4 h following admin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent