BDBM520867 (+/−)-5-({[6-Bromo-3-methyl-2-(piperidin-1-yl)quinolin-4-yl]carbonyl}amino)-4-(2-chloro-3,6-difluorophenyl)pentanoic acid (Racemate)::US11149018, Example 151

SMILES Cc1c(nc2ccc(Br)cc2c1C(=O)NCC(CCC(O)=O)c1c(F)ccc(F)c1Cl)N1CCCCC1

InChI Key InChIKey=VDHJPBNFGKNQMK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 520867   

TargetProstaglandin F2-alpha receptor(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM520867(US11149018, Example 151 | (+/−)-5-({[6-Bromo...)
Affinity DataIC50: 1.30nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM520867(US11149018, Example 151 | (+/−)-5-({[6-Bromo...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM520867(US11149018, Example 151 | (+/−)-5-({[6-Bromo...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM520867(US11149018, Example 151 | (+/−)-5-({[6-Bromo...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetProstaglandin F2-alpha receptor(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM520867(US11149018, Example 151 | (+/−)-5-({[6-Bromo...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed