BDBM523748 US11136312, Compound MM-I-21

SMILES COc1ccccc1Cc1nnc(CCc2c[nH]c3ccccc23)n1CCCc1c[nH]cn1

InChI Key InChIKey=LBHHYXZZVWUQOJ-UHFFFAOYSA-N

Data  10 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 523748   

TargetSomatostatin receptor type 3(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataEC50:  28.9nMAssay Description:Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataEC50:  29nMAssay Description:Agonist activity at recombinant human SST4 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSomatostatin receptor type 4(Human)
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi:  39.5nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi:  40nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from human SST4 receptor expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSomatostatin receptor type 1(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 2(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 3(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 5(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 2(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from human SST2A receptor expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSomatostatin receptor type 1(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from SST1 receptor (unknown origin) expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSomatostatin receptor type 3(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from SST3 receptor (unknown origin) expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSomatostatin receptor type 5(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523748(US11136312, Compound MM-I-21)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from SST5 receptor (unknown origin) expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed