BDBM523753 US11136312, Compound MM-I-63

SMILES N#Cc1cccc(Cc2nnc(CCc3c[nH]c4ccccc34)n2CCCc2c[nH]cn2)c1

InChI Key InChIKey=GBPJQABBBCQFHE-UHFFFAOYSA-N

Data  4 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 523753   

TargetSomatostatin receptor type 3(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523753(US11136312, Compound MM-I-63)
Affinity DataEC50:  75.8nMAssay Description:Measurement of forskolin stimulated inhibition of cAMP was performed via time-resolved fluorescence resonance energy transfer (TR-FRET) LANCE assay (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 4(Human)
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523753(US11136312, Compound MM-I-63)
Affinity DataEC50:  76nMAssay Description:Agonist activity at recombinant human SST4 receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-stimulated cAMP production measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSomatostatin receptor type 4(Human)
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523753(US11136312, Compound MM-I-63)
Affinity DataKi:  30nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from human SST4 receptor expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSomatostatin receptor type 4(Human)
Southern Illinois University Edwardsville

Curated by ChEMBL
LigandPNGBDBM523753(US11136312, Compound MM-I-63)
Affinity DataKi:  30.3nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 2(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523753(US11136312, Compound MM-I-63)
Affinity DataKi: >1.00E+4nMAssay Description:Competitive radioligand binding experiments were performed using MEMBRANE TARGET Systems (Perkin-Elmer, Boston, Mass.) for human somatostatin recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetSomatostatin receptor type 2(Human)
Board of Trustees of The Southern Illinois University

US Patent
LigandPNGBDBM523753(US11136312, Compound MM-I-63)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]-Tyr-SRIF 14 from human SST2A receptor expressed in membrane measured after 90 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed