BDBM524450 2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyridine-2- carbonyl)pyrrolidin-2-yl)-N-((1- aminoisoquinolin-6-yl)methyl)thiazole- 4-carboxamide::US11168083, Example 49

SMILES N[C@@H]1C[C@H](N(C1)C(=O)c1cn2cc(Cl)ccc2n1)c1nc(cs1)C(=O)NCc1ccc2c(N)nccc2c1

InChI Key InChIKey=SYUKSGXOSHFNNI-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 524450   

TargetPlasma kallikrein(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM524450(2-((2S,4R)-4-amino-1-(6- chloroimidazo[1,2-a]pyrid...)
Affinity DataEC50: <100nMAssay Description:Plasma Kallikrein: The example compounds were evaluated for inhibition of the human activated kallikrein enzyme in two formats of an assay employing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
US Patent