BDBM525936 5-chloro-2-fluoro-4-((1-phenylcyclopropyl)amino)-N-(thiazol-2-yl)benzenesulfonamide::US11174268, Example 43

SMILES Fc1cc(NC2(CC2)c2ccccc2)c(Cl)cc1S(=O)(=O)Nc1nccs1

InChI Key InChIKey=BSYXHWAZXDROKV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 525936   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525936(5-chloro-2-fluoro-4-((1-phenylcyclopropyl)amino)-N...)
Affinity DataIC50: 28nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525936(5-chloro-2-fluoro-4-((1-phenylcyclopropyl)amino)-N...)
Affinity DataIC50: 191nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525936(5-chloro-2-fluoro-4-((1-phenylcyclopropyl)amino)-N...)
Affinity DataIC50: 2.14E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525936(5-chloro-2-fluoro-4-((1-phenylcyclopropyl)amino)-N...)
Affinity DataIC50: 4.10E+3nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM525936(5-chloro-2-fluoro-4-((1-phenylcyclopropyl)amino)-N...)
Affinity DataIC50: 1.11E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
US Patent