BDBM527665 US11186589, Compound 44

SMILES CNC(=O)c1cc(Nc2nccc(n2)-c2cc3c(NC[C@]3(C)CO)c(c2)C#N)c(=O)n2CCCc12

InChI Key InChIKey=SNJKGIPRAINBTI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527665   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM527665(US11186589, Compound 44)
Affinity DataIC50: 4.5nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (αscreen) format (Perkin Elmer). All compounds tested were dissolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent