BDBM527726 US11186589, Compound 10c

SMILES COc1nc2n(CC(=O)N(C)C)ccc2cc1Nc1nccc(n1)-c1cc2c(NC[C@]2(C)CO)c(c1)C#N

InChI Key InChIKey=WCUWXJRDNBIGLE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527726   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM527726(US11186589, Compound 10c)
Affinity DataIC50: 4.30nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreen (αscreen) format (Perkin Elmer). All compounds tested were dissolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent