BDBM527819 1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]pyrimidin-5- yl)azepan-4-amine::US11179397, Example 36::US11498930, Compound 1.1.48::US11673901, Compound 2

SMILES CC1(N)CCN(CC1)c1ncc(Sc2ccnc(N)c2Cl)c2nccn12

InChI Key InChIKey=ABPRMEHIXGOXJZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 527819   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM527819(1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]py...)
Affinity DataIC50: 120nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.00005-10 μM) was monitored using an assay in which 0.2 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM527819(1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]py...)
Affinity DataIC50: 275nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.00005-10 μM) was monitored using an assay in which 0.2 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM527819(1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]py...)
Affinity DataIC50: 280nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM527819(1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]py...)
Affinity DataIC50: 550nMAssay Description:Compound powders were dissolved in DMSO to prepare mother liquor.During the experiment, the stock solutions of the compounds were subjected to 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
US Patent