BDBM527826 (1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]pyrimidin-5-yl)-4- methylpiperidin-4- yl)methanamine::US11179397, Example 43::US11498930, Compound 1.1.5

SMILES CC1(CN)CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)c2nccn12

InChI Key InChIKey=HHOJUKLSDZNMON-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 527826   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527826((1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]p...)
Affinity DataIC50: 23nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527826((1-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- c]p...)
Affinity DataIC50: 100nMAssay Description:Compound powders were dissolved in DMSO to prepare mother liquor.During the experiment, the stock solutions of the compounds were subjected to 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2023
Entry Details
US Patent