BDBM527913 (3S,4S)-8-(8-((1H- pyrrolo[2,3- b]pyridin-4- yl)thio)imidazo[1,2- c]pyrimidin-5-yl)- 3-methyl-2-oxa-8- azaspiro[4.5]decan- 4-amine::US11179397, Example 130::US11673901, Compound 15

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4[nH]ccc34)c3nccn23)[C@@H]1N

InChI Key InChIKey=KCNVEVFFCJNHMT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 527913   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527913((3S,4S)-8-(8-((1H- pyrrolo[2,3- b]pyridin-4- yl)th...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Gilead Sciences

US Patent
LigandPNGBDBM527913((3S,4S)-8-(8-((1H- pyrrolo[2,3- b]pyridin-4- yl)th...)
Affinity DataIC50: 50nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.00005-10 μM) was monitored using an assay in which 0.2 nM of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent