BDBM532044 N-[4-(2-Amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3-methoxyphenyl}pyridin-3-yl)-3-fluorophenyl]-1′-[(4-cyanotetrahydro-2H-pyran-4-yl)methyl]-5-methyl-4′-oxo-1′,4′-dihydro-2,3′-bipyridine-5′-carboxamide::US11208403, Example 121

SMILES COc1cc(ccc1OC[C@H]1COCCO1)-c1cnc(N)c(c1)-c1ccc(NC(=O)c2cn(CC3(CCOCC3)C#N)cc(-c3ccc(Br)cn3)c2=O)cc1F

InChI Key InChIKey=YCXZBULDUGDETC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 532044   

TargetTyrosine-protein kinase receptor UFO(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM532044(N-[4-(2-Amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3...)
Affinity DataIC50: 0.800nMAssay Description:A kinase dilution solution containing 170 ng/ml AXL (the 464th to 885th amino acids of the intracellular domain of human AXL expressed as a fusion pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM532044(N-[4-(2-Amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3...)
Affinity DataIC50: 16nMAssay Description:A phosphorylated Axl (hereinafter, referred to as pAxl) inhibition test was conducted using a human non-small cell lung cancer-derived cell line NCI-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
US Patent

TargetTyrosine-protein kinase Mer(Human)
Daiichi Sankyo

US Patent
LigandPNGBDBM532044(N-[4-(2-Amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3...)
Affinity DataIC50: 93nMAssay Description:A kinase dilution solution containing 20 ng/ml Mer (the 528th to 999th amino acids of the intracellular domain of human MER expressed as a fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2022
Entry Details
US Patent