BDBM532798 N2-(1-(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-5-yl)-5-methyl-1H-pyrazol-4-yl)-N4-methyl-5-(trifluoromethyl)pyrimidine-2,4-diamine (D-52)::US11214565, Example D-47

SMILES CCSc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C#N

InChI Key InChIKey=YINAHIXSWNRWAA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 532798   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Denali Therapeutics

US Patent
LigandPNGBDBM532798(US11214565, Example D-47 | N2-(1-(5,6-dihydro-4H-p...)
Affinity DataIC50: 30nMAssay Description:50 mM Tris pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% Brij-35, 2 mM DTT, 5 nM LRRK2, 134 μM ATP, 60 minute reaction time, 23° C. reaction temperature...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2022
Entry Details
US Patent