BDBM5328 2-quinolinone deriv. 3::3-(1H-indol-2-yl)-1,2-dihydroquinolin-2-one::CHEMBL221736

SMILES O=c1[nH]c2ccccc2cc1-c1cc2ccccc2[nH]1

InChI Key InChIKey=OSFGHYZLBDAJTP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5328   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5328(3-(1H-indol-2-yl)-1,2-dihydroquinolin-2-one | CHEM...)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2005
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM5328(3-(1H-indol-2-yl)-1,2-dihydroquinolin-2-one | CHEM...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CHEK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5328(3-(1H-indol-2-yl)-1,2-dihydroquinolin-2-one | CHEM...)
Affinity DataIC50: 8nMAssay Description:Inhibition of VEGFR-2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed