BDBM534889 1-{5-cyano-6-[(3R)-4- (cyclopropylcarbonyl)-3- methylpiperazin-1-yl]-2-(1- methyl-1H-pyrazol-4- yl)pyrimidin-4-yl}-3- cyclobutylurea::US11230547, Compound 6-17

SMILES C[C@@H]1CN(CCN1C(=O)C1CC1)c1nc(nc(NC(=O)NC2CCC2)c1C#N)-c1cnn(C)c1

InChI Key InChIKey=YLRVHLJNYWPOQW-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 534889   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Sharp & Dohme

US Patent

LigandBDBM534889(1-{5-cyano-6-[(3R)-4- (cyclopropylcarbonyl)-3- met...)Copy SMILESCopy InChI

Affinity DataIC50: 5nMAssay Description:This assay was developed and further optimized from a kit produced by Upstate (Millipore catalog #33-047) (Millipore Sigma, Billerica Mass., USA) and...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
5/30/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL