BDBM535260 US11236068, Example 58

SMILES CC1CN([C@H](CC#N)CN1c1nc(OC[C@@H]2C[C@@H](F)CN2C)nc2cc(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C(F)=C

InChI Key InChIKey=HPHSJQXSBYVVOO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535260   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535260(US11236068, Example 58)
Affinity DataIC50: 14nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent