BDBM535265 3-{4-[(1S)-1-[(1R)-1-(4- chlorophenyl)-2-[(4- chlorophenyl)methyl]-7-fluoro-1- methoxy-3-oxo-2,3-dihydro-1H- isoindol-5-yl]-1- hydroxypropyl]piperidin-1- yl}propanoic acid::US11236047, Example 137

SMILES CC[C@](O)(C1CCN(CCC(O)=O)CC1)c1cc2C(=O)N(Cc3ccc(Cl)cc3)[C@](OC)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=ZKUGFHUACFYRES-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535265   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535265(3-{4-[(1S)-1-[(1R)-1-(4- chlorophenyl)-2-[(4- chlo...)
Affinity DataIC50: 0.570nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535265(3-{4-[(1S)-1-[(1R)-1-(4- chlorophenyl)-2-[(4- chlo...)
Affinity DataIC50: 1.60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent