BDBM535404 N-{[1-({[(1R)-1-(4-Chlorophenyl)-2- [(5-chloropyridin-2-yl)methyl]-7-fluoro- 5-(2-hydroxypropan-2-yl)-3-oxo-2,3- dihydro-1H-isoindol-1- yl]oxy}methyl)cyclopropyl]methyl} acetamide::US11236047, Example 156

SMILES CC(=O)NCC1(CO[C@]2(N(Cc3ccc(Cl)cn3)C(=O)c3cc(cc(F)c23)C(C)(C)O)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=OSEHZDAAYCTXDQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535404   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535404(N-{[1-({[(1R)-1-(4-Chlorophenyl)-2- [(5-chloropyri...)
Affinity DataIC50: 1.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent