BDBM535452 1-({[(1R)-2-[(5-chloro-1-oxo-1lambda5- pyridin-2-yl)methyl]-1-(4- chlorophenyl)-7-fluoro-5-[1-hydroxy- 1-(1-methyl-1H-pyrazol-4-yl)ethyl]-3- oxo-2,3-dihydro-1H-isoindol-1- yl]oxy}methyl)cyclopropane-1- carbonitrile::US11236047, Example 408

SMILES Cn1cc(cn1)C(C)(O)c1cc2C(=O)N(Cc3ccc(Cl)c[n+]3[O-])[C@](OCC3(CC3)C#N)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=PPRQBTGGPVRJIV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535452   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535452(1-({[(1R)-2-[(5-chloro-1-oxo-1lambda5- pyridin-2-y...)
Affinity DataIC50: 1.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent