BDBM535464 US11236068, Example 62a::US11236068, Example 62b

SMILES CNc1cc(C)c(c(n1)-c1c(Cl)cc2c(nc(OC[C@@H]3CCCN3C)nc2c1F)N1CCN(C[C@@H]1C)C(=O)C=C)C(F)(F)F

InChI Key InChIKey=DEDIEXJGPBSYTD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535464   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535464(US11236068, Example 62b | US11236068, Example 62a)
Affinity DataIC50: 10nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535464(US11236068, Example 62b | US11236068, Example 62a)
Affinity DataIC50: 710nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent