BDBM535468 US11236068, Example 64a::US11236068, Example 64b

SMILES C[C@H]1CN(CCN1c1nc(OCC2CCC(=O)N2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C=C

InChI Key InChIKey=VMGVHZFDAGEZSY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535468   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535468(US11236068, Example 64b | US11236068, Example 64a)
Affinity DataIC50: 10nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535468(US11236068, Example 64b | US11236068, Example 64a)
Affinity DataIC50: 3.30E+3nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent