BDBM535472 US11236068, Example 67a::US11236068, Example 67b

SMILES C[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)c(F)c2ccccc12)C(=O)C=C

InChI Key InChIKey=JXLZSUBVIWUVBM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535472   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535472(US11236068, Example 67b | US11236068, Example 67a)
Affinity DataIC50: 10nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535472(US11236068, Example 67b | US11236068, Example 67a)
Affinity DataIC50: 73nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent