BDBM535484 US11236068, Example 76

SMILES Nc1ccc(c(n1)-c1cc2nc(OCCN3CC(CF)C3)nc(N3CCN(CC3)C(=O)C=C)c2cc1Cl)C(F)(F)F

InChI Key InChIKey=RIUOMDUNASDBNY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535484   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535484(US11236068, Example 76)
Affinity DataIC50: 13nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent