BDBM535488 US11236068, Example 79a::US11236068, Example 79b

SMILES C[C@H](CN(C)C)Oc1nc(N2CCN(CC2)C(=O)C=C)c2cc(Cl)c(cc2n1)-c1nc(N)ccc1C(F)(F)F

InChI Key InChIKey=LPVFWDFYJHTBJC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535488   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535488(US11236068, Example 79b | US11236068, Example 79a)
Affinity DataIC50: 17nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535488(US11236068, Example 79b | US11236068, Example 79a)
Affinity DataIC50: 22nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent