BDBM535490 US11236068, Example 80

SMILES COCC1CCC(COc2nc(N3CCN(CC3)C(=O)C=C)c3cc(Cl)c(cc3n2)-c2nc(N)ccc2C(F)(F)F)N1C

InChI Key InChIKey=PFOVHRIJRVKJNH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535490   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535490(US11236068, Example 80)
Affinity DataIC50: 10nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent