BDBM535496 US11236068, Example 83b::US11236068, Example 83d

SMILES CN1C[C@H](F)C[C@H]1COc1nc(N2CCN([C@@H](CC#N)C2)C(=O)C(F)=C)c2cc(Cl)c(c(F)c2n1)-c1nc(N)cc(C)c1C(F)(F)F

InChI Key InChIKey=WYVPGAHRCPBJQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535496   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535496(US11236068, Example 83d | US11236068, Example 83b)
Affinity DataIC50: 20nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535496(US11236068, Example 83d | US11236068, Example 83b)
Affinity DataIC50: 2.90E+3nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent