BDBM535503 US11236068, Example 87

SMILES Nc1ccc(c(n1)-c1cc2nc(OC[C@@H]3CCCN3C3COC3)nc(N3CCN(CC3)C(=O)C=C)c2cc1Cl)C(F)(F)F

InChI Key InChIKey=YJQXLGNLYBYWFF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535503   

TargetGTPase KRas [G12C](Human)
Genentech

US Patent
LigandPNGBDBM535503(US11236068, Example 87)
Affinity DataIC50: 23nMAssay Description:To determine the potency of compounds for inhibiting nucleotide exchange, various concentrations were incubated with K-Ras G12C (25 nM in reaction, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent