BDBM535592 4-((2-Hydroxyethyl)sulfonamido)-N- (2-isopropyl-6- methylpyrimidin-4-yl)-2-(6- azaspiro[2.5]octan-6- yl)benzamide::US11236069, Example 11-2

SMILES CC(C)c1nc(C)cc(NC(=O)c2ccc(NS(=O)(=O)CCO)cc2N2CCC3(CC3)CC2)n1

InChI Key InChIKey=PUFLHFFUBAZXAG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535592   

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandPNGBDBM535592(4-((2-Hydroxyethyl)sulfonamido)-N- (2-isopropyl-6-...)
Affinity DataIC50: 27nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent