BDBM535651 5-(6-morpholino-4- (phenylsulfonyl)pyridin-2- yl)thiazol-2-amine::US11236079, Example 5

SMILES Nc1ncc(s1)-c1cc(cc(n1)N1CCOCC1)S(=O)(=O)c1ccccc1

InChI Key InChIKey=GNXRNXYQCPJFIH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535651   

TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Neuropore Therapies

US Patent
LigandPNGBDBM535651(5-(6-morpholino-4- (phenylsulfonyl)pyridin-2- yl)t...)
Affinity DataIC50: 81nMAssay Description:The substrate (Phosphatidylinositol (PI): Phosphatidylserine (PS)) was added to freshly prepared reaction buffer (40 mM Tris-HCl (pH7.5), 3 μM O...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

LigandPNGBDBM535651(5-(6-morpholino-4- (phenylsulfonyl)pyridin-2- yl)t...)
Affinity DataIC50: 502nMAssay Description:Compounds were prepared at 100× final concentration using a 12-point, 1:3 serial-dilution in DMSO, with DMSO control as the 12th point. Compound was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent