BDBM536319 (4S)-3'-[2,6-Difluoro-4-(2- phenylethynyl)phenyl]-1-ethyl- 1'-methyl-spiro[6,7-dihydro-5H- indazole-4,6'- hexahydropyrimidine]-2',4'- dione::US11242349, Example 2

SMILES CCn1ncc2c1CCC[C@]21CC(=O)N(C(=O)N1C)c1c(F)cc(cc1F)C#Cc1ccccc1

InChI Key InChIKey=UASAWRUITKPRGV-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 536319   

TargetMetabotropic glutamate receptor 4(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM536319((4S)-3'-[2,6-Difluoro-4-(2- phenylethynyl)phenyl]-...)
Affinity DataEC50:  85nMAssay Description:A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent